The Vatican is a mini city within Rome (actually it’s considered it’s own country). It is easily accessible via public transport from the Rome Termini. Say a prayer or if your fortunate, hear mass The St. Peter’s Basilica where the Pope resides and drop by and marvel at the beauty of Michelangelo’s work of art at the Vatican Museum. Probably one of the best seasons to visit Vatican is during the holiday season where you could attend a Christmas mass with a lot of people from all over the world. If you plan on attending the Christmas mass it requires an invitation from the Vatican which you have to apply for. Also, there is no gauranteed seating so you should show up early!